SLC30A5 Gene Summary [Human]
This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | SLC30A5 |
| Official Name | solute carrier family 30 member 5 [Source:HGNC Symbol;Acc:HGNC:19089] |
| Ensembl ID | ENSG00000145740 |
| Bio databases IDs | |
| Aliases | solute carrier family 30 member 5 |
| Synonyms | 1810010K08Rik, FLJ12496 FIS, MGC5499, Slc30a5 predicted, solute carrier family 30 member 5, solute carrier family 30 (zinc transporter), member 5, Zip5, ZNT5, ZNTL1, ZTL1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC30A5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- cation diffusion facilitator family transporter
- transmembrane domain
- antiporter
- protein binding
- zinc ion transporter
- Cation efflux family
- metal ion transporter
- cation efflux permease
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- kyphosis
- atrial ventricular block
- growth failure
- sinus bradycardia
- hypopigmentation
role in cell
- growth
- expression in
- quantity
- number
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- perinuclear region
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- secretory granule membrane
- basolateral cell surfaces
- endoplasmic reticulum membrane
- apical membrane
- Golgi membrane
- trans Golgi network
- nucleoplasm
- nucleoli
- cytoplasmic vesicles
- secretory granules
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC30A5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cobalt ion transport
- GPI anchor biosynthetic process
- insulin processing
- zinc ion transport
- cellular zinc ion homeostasis
- zinc ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- secretory granule membrane
- secretory granule
- membrane
- ER to Golgi transport vesicle membrane
- cytoplasmic vesicle
- Golgi apparatus
- Golgi membrane
- nucleolus
- apical plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- antiporter activity
- metal ion binding
- zinc ion transmembrane transporter activity