TUBA1B Gene Summary [Human]
Enables double-stranded RNA binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within cellular response to interleukin-4. Located in microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TUBA1B |
| Official Name | tubulin alpha 1b [Source:HGNC Symbol;Acc:HGNC:18809] |
| Ensembl ID | ENSG00000123416 |
| Bio databases IDs | |
| Aliases | tubulin alpha 1b, tubulin, alpha, ubiquitous |
| Synonyms | K-alpha-1, K alpha 1-TUBULIN, K-α-1, K α 1-TUBULIN, RGD1565476, Tuba1, Tuba2, tubulin alpha 1b, tubulin, alpha 1B, Tubulin alpha 2, tubulin α 1b, tubulin, α 1B, Tubulin α 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TUBA1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- ubiquitin protein ligase binding
- Tubulin protein family of FtsZ and CetZ-like
- Tubulin C-terminal domain
- structural constituent of cytoskeleton
- Tubulin/FtsZ family, GTPase domain
- double-stranded RNA binding
- GTPase
- enzyme
- Tubulin/FtsZ family, C-terminal domain
- protein binding
- structural molecule
Pathways
Biological processes and signaling networks where the TUBA1B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- Parkinson disease
regulates
role in cell
- cell survival
- organization
- response by
- aggregation in
- cell division
- regulation
- regulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- microtubule cytoskeleton
- cilia
- cellular membrane
- Nucleus
- microtubules
- cytosol
- synaptic vesicles
- cytoplasmic microtubule
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TUBA1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- cytoskeleton-dependent intracellular transport
- cellular response to interleukin-4
- microtubule cytoskeleton organization
- mitotic cell cycle
- microtubule-based process
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cytoplasm
- cytoplasmic microtubule
- microtubule
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- ubiquitin protein ligase binding
- double-stranded RNA binding
- GTPase activity
- structural molecule activity
- structural constituent of cytoskeleton