SH2D1B Gene Summary [Human]
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | SH2D1B |
| Official Name | SH2 domain containing 1B [Source:HGNC Symbol;Acc:HGNC:30416] |
| Ensembl ID | ENSG00000198574 |
| Bio databases IDs | |
| Aliases | SH2 domain containing 1B |
| Synonyms | EAT-2, RGD1563935, Sh2d1b1, SH2 domain containing 1B |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SH2D1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- Src homology 2 (SH2) domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SH2D1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of innate immune response
- innate immune response
- positive regulation of natural killer cell mediated immunity
- adaptive immune response
- leukocyte activation involved in immune response
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein binding, bridging