CD84 Gene Summary [Human]
This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | CD84 |
| Official Name | CD84 molecule [Source:HGNC Symbol;Acc:HGNC:1704] |
| Ensembl ID | ENSG00000066294 |
| Bio databases IDs | |
| Aliases | CD84 molecule |
| Synonyms | A130013D22Rik, CD84 antigen, CD84 molecule, CDW84, hCD84, leukocyte antigen CD84, LY9B, mCD84, RGD1564553, SLAMF5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD84 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- cytoplasmic domain
- immunoglobulin domain
- protein binding
- cytosolic tail domain
- identical protein binding
- Immunoglobulin V-set domain
- tyrosine-based motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- renal clear cell adenocarcinoma
- renal clear cell cancer
- androgenic alopecia
- early-onset preeclampsia
- multisystem inflammatory syndrome in children
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- diabetic nephropathy
role in cell
- proliferation
- activation
- activation in
- quantity
- adhesion
- binding
- number
- abnormal morphology
- killing by
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD84 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of monocyte chemotactic protein-1 production
- T cell activation
- adaptive immune response
- homophilic cell adhesion
- defense response
- negative regulation of mast cell degranulation
- negative regulation of interleukin-6 production
- regulation of macrophage activation
- innate immune response
- autophagy
- negative regulation of granulocyte macrophage colony-stimulating factor production
- negative regulation of mast cell activation
- positive regulation of tumor necrosis factor production
- negative regulation of interleukin-18 production
- regulation of store-operated calcium entry
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding