SLAMF1 Gene Summary [Human]
Enables SH2 domain binding activity and identical protein binding activity. Involved in several processes, including negative regulation of CD40 signaling pathway; negative regulation of cytokine production; and positive regulation of MAPK cascade. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLAMF1 |
| Official Name | signaling lymphocytic activation molecule family member 1 [Source:HGNC Symbol;Acc:HGNC:10903] |
| Ensembl ID | ENSG00000117090 |
| Bio databases IDs | |
| Aliases | signaling lymphocytic activation molecule family member 1 |
| Synonyms | 4933415F16, CD150, CDw150, ESTM51, IPO-3, RGD1560634, signaling lymphocytic activation molecule family member 1, SLAM |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLAMF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- viral receptor
- SH2-domain binding
- immunoglobulin domain
- cell adhesion molecule binding
- ectodomain
- antigen binding
- protein binding
- V domain
- identical protein binding
- cytoplasmic domain
- Signaling lymphocytic activation molecule (SLAM) protein
- cytosolic tail domain
- transmembrane receptor
- tyrosine phosphorylation site
- immunoreceptor tyrosine switch motif
- tyrosine-based motif
Pathways
Biological processes and signaling networks where the SLAMF1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- diabetic nephropathy
- eczema
- Crohn disease
- tuberculoid leprosy
- cerebral hemorrhage
- infection by parasite
role in cell
- inhibition in
- expression in
- proliferation
- apoptosis
- activation in
- chemotaxis
- differentiation
- signaling in
- activation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cell-cell contacts
- plasma membrane extracellular face
- recycling endosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLAMF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- positive regulation of cell proliferation
- cell adhesion
- regulation of vesicle fusion
- natural killer cell proliferation
- positive regulation of macrophage chemotaxis
- positive regulation of interferon-gamma production
- positive regulation of dendritic cell chemotaxis
- positive regulation of T-helper 1 cell cytokine production
- negative regulation of interferon-gamma production
- negative regulation of tumor necrosis factor production
- adaptive immune response
- positive regulation of activated T cell proliferation
- leukocyte chemotaxis involved in inflammatory response
- myeloid dendritic cell activation involved in immune response
- negative regulation of interleukin-6 production
- negative regulation of CD40 signaling pathway
- positive regulation of JNK cascade
- innate immune response
- negative regulation of T cell cytokine production
- natural killer cell differentiation
- positive regulation of ERK1 and ERK2 cascade
- phagocytosis
- negative regulation of interleukin-12 production
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- phagocytic vesicle
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transmembrane signaling receptor activity
- antigen binding
- signaling receptor activity
- viral receptor activity
- SH2 domain binding