SMURF1 Gene Summary [Human]
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | SMURF1 |
| Official Name | SMAD specific E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:16807] |
| Ensembl ID | ENSG00000198742 |
| Bio databases IDs | |
| Aliases | SMAD specific E3 ubiquitin protein ligase 1 |
| Synonyms | 4930431E10RIK, mKIAA1625, RGD1309707, SMAD specific E3 ubiquitin protein ligase 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SMURF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- SMAD binding
- catalytic domain
- ubiquitin protein ligase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- WW class I binding domain
- linker domain
- enzyme
- protein binding
- receptor binding
- WW domain
- HECTc
- Domain with 2 conserved Trp (W) residues
- transforming growth factor-beta receptor binding
- ubiquitin-protein transferase activity
- WW
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Pathways
Biological processes and signaling networks where the SMURF1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- major depression
- pancreatic cancer
- organismal death
- colorectal cancer
- exencephaly
- early-onset preeclampsia
- hepatic steatosis
- spina bifida
- thyroid cancer
role in cell
- cell viability
- expression in
- phosphorylation in
- proliferation
- function
- activity
- activation in
- autophagy in
- apoptosis
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- nucleoplasm
- cellular protrusions
- filopodia
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SMURF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- protein polyubiquitination
- positive regulation of axon extension
- ectoderm development
- protein export from nucleus
- ubiquitin-dependent protein catabolic process
- negative regulation of BMP signaling pathway
- receptor catabolic process
- proteasomal ubiquitin-dependent protein catabolic process
- protein targeting to vacuole involved in autophagy
- negative regulation of activin receptor signaling pathway
- BMP signaling pathway
- cell differentiation
- Wnt receptor signaling pathway, planar cell polarity pathway
- negative regulation of transforming growth factor beta receptor signaling pathway
- protein localization in plasma membrane
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- cytosol
- neuronal cell body
- plasma membrane
- axon
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- SMAD binding
- transforming growth factor beta receptor binding
- R-SMAD binding
- I-SMAD binding
- activin receptor binding
- phospholipid binding