PJA2 Gene Summary [Human]
Enables protein kinase A catalytic subunit binding activity; protein kinase A regulatory subunit binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of macrophage activation; and regulation of signal transduction. Located in cytoplasm; intermediate filament cytoskeleton; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PJA2 |
| Official Name | praja ring finger ubiquitin ligase 2 [Source:HGNC Symbol;Acc:HGNC:17481] |
| Ensembl ID | ENSG00000198961 |
| Bio databases IDs | |
| Aliases | praja ring finger ubiquitin ligase 2 |
| Synonyms | AI447901, mKIAA0438, Neurodap1, praja2, praja ring finger ubiquitin ligase 2, RNF131 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PJA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- protein kinase binding
- ubiquitin protein ligase activity
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- non-insulin-dependent diabetes mellitus
- hydronephrosis
- edema
role in cell
- signaling in
- outgrowth
- degradation in
- extension
- ubiquitination in
- extension in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- intermediate filament cytoskeleton
- postsynaptic region
- Plasma Membrane
- basal bodies
- centrosome
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PJA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-term memory
- inflammatory response
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of macrophage activation
- regulation of protein kinase A signaling cascade
- innate immune response
- positive regulation of JNK cascade
- positive regulation of toll-like receptor 2 signaling pathway
- protein ubiquitination
- positive regulation of p38MAPK cascade
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- postsynaptic density
- centrosome
- intermediate filament cytoskeleton
- cytoplasm
- cilium basal body
- centriolar satellite
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding
- protein kinase A regulatory subunit binding
- protein kinase A catalytic subunit binding