MIR210 Gene Summary [Human]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Details
| Type | Micro RNA |
| Official Symbol | MIR210 |
| Official Name | microRNA 210 [Source:HGNC Symbol;Acc:HGNC:31587] |
| Ensembl ID | ENSG00000199038 |
| Bio databases IDs | |
| Aliases | microRNA 210 |
| Synonyms | HSA-MIR-210, microRNA 210, MIRN210, miRNA210, mmu-miR-210, pri-miR-210, rno-miR-210 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MIR210 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- translation repressor
- mRNA binding
- microRNA
Pathways
Biological processes and signaling networks where the MIR210 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- ulcerative colitis
- liver cirrhosis
- polymyositis
- congenital adrenal hyperplasia
- dermatomyositis
- breast cancer
- neoplasia
- ischemia
- epithelial cancer
role in cell
- survival
- expression in
- cell death
- apoptosis
- function
- production in
- phosphorylation in
- migration
- differentiation
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MIR210 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translation involved in gene silencing by miRNA
- gene silencing by miRNA
- regulation of cellular response to hypoxia
- positive regulation of osteoblast differentiation
- positive regulation of angiogenesis
- positive regulation of blood vessel endothelial cell migration
- negative regulation of BMP signaling pathway
- negative regulation of neuron projection development
- negative regulation of cytokine production
- mRNA cleavage involved in gene silencing by miRNA
- tube formation
- negative regulation of apoptotic signaling pathway
- positive regulation of cell migration
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- RNA-induced silencing complex
Molecular Function
What the gene product does at the molecular level
- mRNA 3'-UTR binding