NUP210 Gene Summary [Human]
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | NUP210 |
| Official Name | nucleoporin 210 [Source:HGNC Symbol;Acc:HGNC:30052] |
| Ensembl ID | ENSG00000132182 |
| Bio databases IDs | |
| Aliases | nucleoporin 210 |
| Synonyms | 9830001L10, Gp120, gp190, GP210, nucleoporin 210, POM210 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NUP210 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bacterial Ig-like domain (group 2)
- protein binding
- Bacterial Ig-like domain 2
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- metastasis
- COVID-19
- coronary artery disease
- liver cancer
- hepatocellular carcinoma
- neonatal late-onset sepsis
role in cell
- expression in
- differentiation
- activation in
- proliferation
- cell viability
- function
- area
- number
- abnormal morphology
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear pores
- inner nuclear membrane
- nuclear rim
- nuclear envelope
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NUP210 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleocytoplasmic transport
- protein transport
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- nuclear membrane
- membrane
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein binding