GPS1 Gene Summary [Human]
This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]
Details
| Type | Processed Transcript |
| Official Symbol | GPS1 |
| Official Name | G protein pathway suppressor 1 [Source:HGNC Symbol;Acc:HGNC:4549] |
| Ensembl ID | ENSG00000169727 |
| Bio databases IDs | |
| Aliases | G protein pathway suppressor 1, COP9 signalosome subunit 1 |
| Synonyms | COPS1, CSN1, G protein pathway suppressor 1, MFH, SGN1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- GTPase inhibitor
- protein binding
- 26S proteasome subunit RPN7
Pathways
Biological processes and signaling networks where the GPS1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- cutaneous melanoma cancer
- placental cancer
role in cell
- expression in
- phosphorylation in
- degradation in
- crizotinib sensitivity
- homologous recombination in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deneddylation
- protein neddylation
- JNK cascade
- regulation of protein neddylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- signalosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase inhibitor activity