DEFB110
DEFB110 Gene Summary
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Details
| Type | Protein Coding |
| Official Symbol | DEFB110 |
| Official Name | defensin beta 110 [Source:HGNC Symbol;Acc:HGNC:18091] |
| Ensembl ID | ENSG00000203970 |
| Bio databases IDs | |
| Aliases | defensin beta 110 |
| Synonyms | 9230102D03Rik,BD-17,Bd-41,DEFB-10,DEFB-11,DEFB111,Defb16,Defb17,Defb41,defensin beta 110,defensin beta 17,defensin beta 41,defensin β 110,defensin β 17,defensin β 41,Gm15386 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta defensin
Pathways
Biological processes and signaling networks where the DEFB110 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- GRN
- ADAM11
- PICK1
- HLA-DQA1
- CTBS
- HSPA5
- UBR2
- TMEM67
- ARMC8
- CAMKMT
disease
regulated by
regulates
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the DEFB110 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive chemotaxis
- innate immune response
- defense response to bacterium
- cell chemotaxis
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
MOLECULAR FUNCTION
What the gene product does at the molecular level
- chemoattractant activity
- CCR6 chemokine receptor binding