CARD16 Gene Summary [Human]
Enables several functions, including CARD domain binding activity; cysteine-type endopeptidase inhibitor activity; and enzyme binding activity. Involved in several processes, including negative regulation of cysteine-type endopeptidase activity; regulation of gene expression; and regulation of signal transduction. Part of protease inhibitor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | CARD16 |
| Official Name | caspase recruitment domain family member 16 [Source:HGNC Symbol;Acc:HGNC:33701] |
| Ensembl ID | ENSG00000204397 |
| Bio databases IDs | |
| Aliases | caspase recruitment domain family member 16 |
| Synonyms | caspase recruitment domain family member 16, COP, COP1, LLID-114769, PSEUDO-ICE |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CARD16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- Caspase recruitment domain
- cysteine protease inhibitor activity
- kinase binding
- protease binding
- protein binding
- identical protein binding
- Death Domain Superfamily of protein-protein interaction domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sarcoidosis
- neonatal asphyxia
- serous ovarian adenocarcinoma
- serous ovarian cancer
- androgenic alopecia
- infection by HIV-1
role in cell
- accumulation in
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CARD16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- negative regulation of tumor necrosis factor-mediated signaling pathway
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of interleukin-1 beta production
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of inflammatory response
- negative regulation of protein binding
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of lipopolysaccharide-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- protease inhibitor complex
- AIM2 inflammasome complex
- IPAF inflammasome complex
- macromolecular complex
- NLRP3 inflammasome complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- cysteine-type endopeptidase inhibitor activity
- CARD domain binding
- kinase binding