ABHD16A Gene Summary [Human]
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Details
| Type | Retained Intron |
| Official Symbol | ABHD16A |
| Official Name | abhydrolase domain containing 16A, phospholipase [Source:HGNC Symbol;Acc:HGNC:13921] |
| Ensembl ID | ENSG00000204427 |
| Bio databases IDs | |
| Aliases | abhydrolase domain containing 16A, phospholipase |
| Synonyms | abhydrolase domain containing 16A, abhydrolase domain containing 16A, phospholipase, BAT5, D17H6S82E, D6S82E, hBAT5, mBAT5, NG26, PP199, SPG86 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ABHD16A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acylglycerol lipase
- enzyme
- protein binding
- phospholipase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- autosomal recessive spastic paraplegia type 86
- postmenopausal osteoporosis
- complicated hereditary spastic paraplegia
- inguinal hernia
- Takayasu arteritis
regulates
- phosphatidylserine
- monoacylglycerol
- prostaglandin
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ABHD16A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- monoacylglycerol catabolic process
- phosphatidylserine catabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- lysophospholipase activity
- acylglycerol lipase activity
- protein binding
- phospholipase activity