Abhd16a Gene Summary [Mouse]
Enables monoacylglycerol lipase activity and phospholipase activity. Involved in monoacylglycerol catabolic process; phosphatidylserine catabolic process; and prostaglandin catabolic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 86. Orthologous to human ABHD16A (abhydrolase domain containing 16A, phospholipase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Abhd16a |
| Official Name | abhydrolase domain containing 16A [Source:MGI Symbol;Acc:MGI:99476] |
| Ensembl ID | ENSMUSG00000007036 |
| Bio databases IDs | |
| Aliases | abhydrolase domain containing 16A |
| Synonyms | abhydrolase domain containing 16A, abhydrolase domain containing 16A, phospholipase, BAT5, D17H6S82E, D6S82E, hBAT5, mBAT5, NG26, PP199, SPG86 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abhd16a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acylglycerol lipase
- enzyme
- protein binding
- phospholipase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- autosomal recessive spastic paraplegia type 86
- postmenopausal osteoporosis
- complicated hereditary spastic paraplegia
- inguinal hernia
- Takayasu arteritis
regulated by
- ZNF106
- RYR1
regulates
- phosphatidylserine
- monoacylglycerol
- prostaglandin
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abhd16a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- monoacylglycerol catabolic process
- phosphatidylserine catabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- lysophospholipase activity
- acylglycerol lipase activity
- protein binding
- phospholipase activity