NCR3 Gene Summary [Human]
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Details
| Type | Processed Transcript |
| Official Symbol | NCR3 |
| Official Name | natural cytotoxicity triggering receptor 3 [Source:HGNC Symbol;Acc:HGNC:19077] |
| Ensembl ID | ENSG00000204475 |
| Bio databases IDs | |
| Aliases | natural cytotoxicity triggering receptor 3 |
| Synonyms | 1C7, CD337, LY117, MALS, natural cytotoxicity triggering receptor 3, NKp30 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- ligand-binding domain
- immunoglobulin domain
- stalk region
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- identical protein binding
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the NCR3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- plasma cell myeloma
- Rett syndrome
- susceptibility to mild malaria
- Sjögren syndrome
- lung cancer
- susceptibility to severe malaria
- systemic sclerosis
- inguinal hernia
- systemic lupus erythematosus
role in cell
- expression in
- phosphorylation in
- degradation in
- replication in
- production in
- activation in
- activation
- cytotoxic reaction
- killing
- lysis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- immune response
- immune response-activating cell surface receptor signaling pathway
- cell recognition
- natural killer cell activation
- positive regulation of natural killer cell mediated cytotoxicity
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding