TRIM27 Gene Summary [Human]
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRIM27 |
| Official Name | tripartite motif containing 27 [Source:HGNC Symbol;Acc:HGNC:9975] |
| Ensembl ID | ENSG00000204713 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 27 |
| Synonyms | Gm19403, LOC100502832, RFP, RFP1, RNF76, tripartite motif-containing 27 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- SUMO transferase activity
- SPRY domain
- nucleic acid binding
- RING B-box domain
- RFP domain
- zinc finger of C3HC4-type, RING
- ubiquitin protein ligase activity
- metal ion binding
- coiled-coil domain
- Ring finger domain
- protein binding
- identical protein binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- B-box zinc finger
- Box B domain
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- inguinal hernia
- hyperthyroidism
- schizophrenia
role in cell
- production in
- apoptosis
- cell death
- degradation in
- differentiation
- stabilization
- autophagy by
- stabilization in
- influx in
- innate immune response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- Cytoplasm
- endosomes
- cytosol
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of type I interferon production
- negative regulation of gene expression, epigenetic
- protein sumoylation
- spermatogenesis
- retrograde transport, endosome to Golgi
- positive regulation of sequence-specific DNA binding transcription factor activity
- negative regulation of calcium ion import
- negative regulation of protein kinase activity
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of adaptive immune response
- negative regulation of interleukin-2 production
- positive regulation of transcription, DNA-dependent
- innate immune response
- negative regulation of autophagy
- positive regulation of interferon-gamma production
- Arp2/3 complex-mediated actin nucleation
- protein K63-linked ubiquitination
- positive regulation of actin nucleation
- negative regulation of tumor necrosis factor production
- negative regulation of viral transcription
Cellular Component
Where in the cell the gene product is active
- PML body
- nucleolus
- fibrillar center
- nucleoplasm
- nucleus
- early endosome
- nuclear membrane
- endosome
- cytoplasm
- mitochondrion
- retromer complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- ubiquitin-protein ligase activity
- DNA binding
- zinc ion binding
- identical protein binding
- protein binding
- transcription coactivator activity
- metal ion binding
- SUMO ligase activity