MIR130A
MIR130A Gene Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Details
| Type | Micro RNA |
| Official Symbol | MIR130A |
| Official Name | microRNA 130a [Source:HGNC Symbol;Acc:HGNC:31514] |
| Ensembl ID | ENSG00000208009 |
| Bio databases IDs | |
| Aliases | microRNA 130a |
| Synonyms | bta-mir-130a,cfa-mir-130a,HSA-MIR-130,hsa-miR-130a,hsa-miR-130b,hsa-miR-301,hsa-miR-301a,hsa-miR-301b,microRNA 130,microRNA 130a,microRNA 130b,microRNA 301,microRNA 301a,microRNA 301b,MIR130A,MIR130B,MIR301,MIR301A,MIR301B,Mirn130,MIRN130A,MIRN130B,MIRN301,MIRN301A,MIRN301B,miRNA130A,mml-mir-130a,Mmu-mir-130,mmu-miR-130a,mmu-miR-130b,mmu-miR-301,mmu-miR-301a,mmu-miR-301b,rno-miR-130a,rno-miR-130b,rno-miR-301,rno-miR-301a,rno-miR-301b,ssc-mir-130a |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- translation repressor
- mRNA binding
- microRNA
Pathways
Biological processes and signaling networks where the MIR130A gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TP53
- CEBPB
- TGFBR1
- CEBPE
- KLF4
- MAFB
- IRF8
- NKRF
disease
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- HER2 negative hormone receptor negative breast cancer
- prostate cancer
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- nemaline myopathy
regulated by
- cisplatin
- tetradecanoylphorbol acetate
- RB1
- PPARA
- megakaryocytes
- hematopoietic progenitor cells
- genomic DNA
- TGFB1
- tretinoin
- ESR1
regulates
- IL1B
- LCN2
- IL17A
- TNF
- IL6
- ERK1/2
- NFkB (complex)
- paclitaxel
- PTGS2
- RELA
role in cell
- expression in
- activation
- production in
- apoptosis
- growth
- migration
- proliferation
- maturation
- tubulation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MIR130A gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- inflammatory response
- negative regulation of monooxygenase activity
- gene silencing by miRNA
- negative regulation of macrophage derived foam cell differentiation
- mRNA cleavage involved in gene silencing by miRNA
- negative regulation of cholesterol efflux
- lipoprotein transport
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
MOLECULAR FUNCTION
What the gene product does at the molecular level
- mRNA 3'-UTR binding