CFAP45 Gene Summary [Human]
Enables AMP binding activity. Involved in establishment of left/right asymmetry and flagellated sperm motility. Located in 9+2 motile cilium; axoneme; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | CFAP45 |
| Official Name | cilia and flagella associated protein 45 [Source:HGNC Symbol;Acc:HGNC:17229] |
| Ensembl ID | ENSG00000213085 |
| Bio databases IDs | |
| Aliases | cilia and flagella associated protein 45 |
| Synonyms | 1700028D05Rik, CCDC19, cilia and flagella associated protein 45, HTX11, NESG1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CFAP45 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AMP binding
- Trichohyalin-plectin-homology domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- mesothelioma formation
- malignant pleural mesothelioma
- pleural cancer
- autosomal visceral heterotaxy 11 with male infertility
- tumorigenesis
role in cell
- proliferation
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- motile cilia
- cilia
- axonemes
- nucleoplasm
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CFAP45 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cilium movement involved in determination of left/right asymmetry
- sperm motility
- regulation of cilium beat frequency involved in ciliary motility
Cellular Component
Where in the cell the gene product is active
- nucleus
- axonemal microtubule
- extracellular region
- axoneme
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- AMP binding