Cfap45

Predicted to enable AMP binding activity. Involved in flagellated sperm motility. Acts upstream of or within cerebrospinal fluid circulation; epithelial cilium movement involved in determination of left/right asymmetry; and regulation of cilium beat frequency involved in ciliary motility. Located in 9+0 motile cilium. Is active in axonemal B tubule inner sheath and sperm flagellum. Is expressed in lateral ventricle choroid plexus; lung; metencephalon part of 4th ventricle choroid plexus; and olfactory epithelium. Human ortholog(s) of this gene implicated in visceral heterotaxy 11. Orthologous to human CFAP45 (cilia and flagella associated protein 45). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cfap45 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Cfap45 gene, providing context for its role in the cell.