SUPT4H1 Gene Summary [Human]
This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
Details
| Type | Processed Transcript |
| Official Symbol | SUPT4H1 |
| Official Name | SPT4 homolog, DSIF elongation factor subunit [Source:HGNC Symbol;Acc:HGNC:11467] |
| Ensembl ID | ENSG00000213246 |
| Bio databases IDs | |
| Aliases | SPT4 homolog, DSIF elongation factor subunit |
| Synonyms | SPT4, SPT4A, DSIF elongation factor subunit, SPT4H, SPT4 homolog, DSIF elongation factor subunit, Supt4a, SUPT4H, Supt4h1a, Supt4h2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SUPT4H1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding
- protein heterodimerization
- Transcription elongation factor Spt4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SUPT4H1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription elongation from RNA polymerase II promoter
- regulation of transcription elongation from RNA polymerase II promoter
- regulation of transcription, DNA-dependent
- negative regulation of transcription elongation, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription elongation, DNA-dependent
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- DSIF complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- protein heterodimerization activity
- RNA polymerase II core binding