Supt4a Gene Summary [Mouse]
Predicted to enable RNA polymerase II complex binding activity and protein heterodimerization activity. Acts upstream of or within negative regulation of transcription elongation by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of DSIF complex. Is expressed in several structures, including cerebral cortex; genitourinary system; liver; lung; and spleen. Orthologous to human SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Supt4a |
| Official Name | SPT4A, DSIF elongation factor subunit [Source:MGI Symbol;Acc:MGI:107416] |
| Ensembl ID | ENSMUSG00000020485 |
| Bio databases IDs | |
| Aliases | SPT4A, DSIF elongation factor subunit |
| Synonyms | SPT4, SPT4A, DSIF elongation factor subunit, SPT4H, SPT4 homolog, DSIF elongation factor subunit, Supt4a, SUPT4H, Supt4h1a, Supt4h2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Supt4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding
- protein heterodimerization
- Transcription elongation factor Spt4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Supt4a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription elongation from RNA polymerase II promoter
- regulation of transcription elongation from RNA polymerase II promoter
- regulation of transcription, DNA-dependent
- negative regulation of transcription elongation, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription elongation, DNA-dependent
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- DSIF complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- protein heterodimerization activity
- RNA polymerase II core binding