MAGEA12 Gene Summary [Human]
This gene is closely related to several other genes clustered on chromosome X. These genes may be overexpressed in tumors. Multiple alternatively spliced variants encoding the same protein have been identified. [provided by RefSeq, Jun 2014]
Details
| Type | Protein Coding |
| Official Symbol | MAGEA12 |
| Official Name | MAGE family member A12 [Source:HGNC Symbol;Acc:HGNC:6799] |
| Ensembl ID | ENSG00000213401 |
| Bio databases IDs | |
| Aliases | MAGE family member A12, cancer/testis antigen family 1, member 12 |
| Synonyms | CT1.12, LOC101060230, MAGE12, MAGE family member A12 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAGEA12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Melanoma associated antigen family N terminal
- MAGE homology domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- organismal death
- esophageal carcinoma formation
- neuroblastoma
- neuroblastoma formation
- undifferentiated sarcoma
- esophageal adenocarcinoma
- osteosarcoma
- osteosarcomagenesis
role in cell
- destruction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAGEA12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding