HBE1 Gene Summary [Human]
The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3' [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HBE1 |
| Official Name | hemoglobin subunit epsilon 1 [Source:HGNC Symbol;Acc:HGNC:4830] |
| Ensembl ID | ENSG00000213931 |
| Bio databases IDs | |
| Aliases | hemoglobin subunit epsilon 1 |
| Synonyms | epsilon gamma globin, Epsilon y2 globin, Epsilon y globin, Ey, Ey-globin, GLOBIN epsilon, GLOBIN ε, haemoglobin subunit epsilon 1, haemoglobin subunit ε 1, haemoglobin Y, beta-like embryonic chain, haemoglobin Y, β-like embryonic chain, Hbb-y, HBE, Hby, hemoglobin subunit epsilon 1, hemoglobin subunit ε 1, hemoglobin Y, beta-like embryonic chain, hemoglobin Y, β-like embryonic chain, LOC100503273, ε globin, ε y2 globin, ε y globin, ε γ globin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HBE1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Globin
- oxygen transporter
- binding protein
- Globin-like protein superfamily
- protein binding
- hemoglobin binding
Pathways
Biological processes and signaling networks where the HBE1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pneumonia
- renal cell carcinoma
- renal cell cancer
- early missed abortion
- severe acute respiratory syndrome
- thromboembolism
regulates
- oxygen
- DNA promoter
- DNA endogenous promoter
- histone H3
- RNA polymerase II
- HBE1
- NF-Y
role in cell
- deformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HBE1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oxygen transport
- carbon dioxide transport
- response to organic cyclic compound
- hydrogen peroxide catabolic process
Cellular Component
Where in the cell the gene product is active
- hemoglobin complex
- haptoglobin-hemoglobin complex
- blood microparticle
- cytosol
Molecular Function
What the gene product does at the molecular level
- oxygen binding
- peroxidase activity
- protein binding
- metal ion binding
- organic acid binding
- hemoglobin alpha binding
- oxygen transporter activity
- heme binding
- haptoglobin binding