PHB2 Gene Summary [Human]
Enables several functions, including protein C-terminus binding activity; protein N-terminus binding activity; and protein dimerization activity. Involved in several processes, including defense response to virus; positive regulation of cell cycle phase transition; and regulation of transcription, DNA-templated. Located in several cellular components, including cell surface; mitochondrial membrane; and nuclear matrix. Part of mitochondrial prohibitin complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | PHB2 |
| Official Name | prohibitin 2 [Source:HGNC Symbol;Acc:HGNC:30306] |
| Ensembl ID | ENSG00000215021 |
| Bio databases IDs | |
| Aliases | prohibitin 2, B cell receptor associated protein 37 |
| Synonyms | BAP, Bap-37, Bcap27, BCAP37, BCR ASSOCIATED protein37, hBAP, p22, PNAS-141, PROHIBITIN 2, REA, TERP1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PHB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- sphingolipid binding
- dimerization domain
- LXXLL motif
- SPFH_like
- alpha helix
- protein binding
- identical protein binding
- binding protein
- prohibitin homologues
- HflC protein
- protein homodimerization
- SPFH domain / Band 7 family
- tyrosine phosphorylation site
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- weight gain
- colorectal cancer
- liver damage
- hypoglycemia
- Alzheimer disease
- gastric cancer
- neuroinflammation
- myocardial dysfunction
- myocardial fibrosis
role in cell
- phosphorylation in
- apoptosis
- expression in
- proliferation
- differentiation
- migration
- tubulation
- activation
- cell viability
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cell surface
- cell periphery
- cellular membrane
- Nucleus
- Plasma Membrane
- Mitochondria
- lipid droplets
- mitochondrial membrane
- mitochondrial nucleoids
- mitochondrial outer membrane
- mitochondrial inner membrane
- inner nuclear membrane
- nuclear matrix
- synapse
- membrane rafts
- axons
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PHB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of branching involved in mammary gland duct morphogenesis
- B cell activation
- positive regulation of sequence-specific DNA binding transcription factor activity
- mammary gland branching involved in thelarche
- regulation of cardiolipin metabolic process
- positive regulation of exit from mitosis
- regulation of complement activation
- mammary gland alveolus development
- negative regulation of transcription, DNA-dependent
- positive regulation of immunoglobulin production
- mammary gland epithelial cell proliferation
- cellular response to hypoxia
- cell migration
- intracellular estrogen receptor signaling pathway
- sister chromatid cohesion
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of MAPK cascade
- macromitophagy
- mitochondrion organization
- CD40 signaling pathway
- cellular response to retinoic acid
- negative regulation of apoptotic process
- protein import into nucleus
- positive regulation of ERK1 and ERK2 cascade
- RIG-I signaling pathway
- negative regulation of intracellular estrogen receptor signaling pathway
- protein stabilization
- negative regulation of mammary gland epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- mitochondrial outer membrane
- plasma membrane
- mitochondrial inner membrane
- cell surface
- nucleus
- presynaptic active zone
- cytoplasm
- mitochondrion
- nuclear matrix
- macromolecular complex
- mitochondrial prohibitin complex
- axon
- cell periphery
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- estrogen receptor binding
- amide binding
- sphingolipid binding