PRPS1L1 Gene Summary [Human]
This intronless gene is specifically expressed in the testis, and encodes a protein that is highly homologous to the two subunits of phosphoribosylpyrophosphate synthetase encoded by human X-linked genes, PRPS1 and PRPS2. These enzymes convert pyrimidine, purine or pyridine bases to the corresponding ribonucleoside monophosphates. In vitro transcription/translation and site-directed mutagenesis studies indicate that translation of this mRNA initiates exclusively at a non-AUG (ACG) codon. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PRPS1L1 |
| Official Name | phosphoribosyl pyrophosphate synthetase 1 like 1 [Source:HGNC Symbol;Acc:HGNC:9463] |
| Ensembl ID | ENSG00000229937 |
| Bio databases IDs | |
| Aliases | phosphoribosyl pyrophosphate synthetase 1 like 1 |
| Synonyms | 1700011K15RIK, phosphoribosyl pyrophosphate synthetase 1-like 1, PRPS1, PRPS3, PRPSL, PRS-III |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRPS1L1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- ATP binding
- ribose-phosphate diphosphokinase
- protein homodimerization
- ribose-phosphate pyrophosphokinase
- Phosphoribosyl transferase (PRT)-type I domain
- Phosphoribosyl synthetase-associated domain
- N-terminal domain of ribose phosphate pyrophosphokinase
- PRK00934
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRPS1L1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribonucleoside monophosphate biosynthetic process
- male gonad development
- purine nucleotide biosynthetic process
- 5-phosphoribose 1-diphosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- ribose phosphate diphosphokinase complex
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein homodimerization activity
- ribose phosphate diphosphokinase activity
- kinase activity