ENY2 Gene Summary [Human]
Enables nuclear receptor coactivator activity. Involved in histone deubiquitination; poly(A)+ mRNA export from nucleus; and positive regulation of transcription, DNA-templated. Located in mitochondrion and nucleoplasm. Part of nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | ENY2 |
| Official Name | ENY2 transcription and export complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:24449] |
| Ensembl ID | ENSG00000120533 |
| Bio databases IDs | |
| Aliases | ENY2 transcription and export complex 2 subunit |
| Synonyms | 1810057B09Rik, 6720481I12, DC6, ENY2 transcription and export complex 2 subunit, ENY2, transcription and export complex 2 subunit, Ey2, e(y)2, LOC682575, Sus1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ENY2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- Transcription factor e(y)2
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ENY2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of insulin secretion involved in cellular response to glucose stimulus
- positive regulation of transcription, DNA-dependent
- regulation of DNA repair
- regulation of RNA splicing
- protein transport
- chromatin organization
- poly(A)+ mRNA export from nucleus
- regulation of transcription from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor TFTC complex
- DUBm complex
- mitochondrion
- transcription export complex 2
- SAGA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- chromatin binding