CDK3 Gene Summary [Human]
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CDK3 |
| Official Name | cyclin dependent kinase 3 [Source:HGNC Symbol;Acc:HGNC:1772] |
| Ensembl ID | ENSG00000250506 |
| Bio databases IDs | |
| Aliases | cyclin dependent kinase 3 |
| Synonyms | cyclin dependent kinase 3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- cyclin-dependent protein kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- protein binding
- Protein kinase domain
Pathways
Biological processes and signaling networks where the CDK3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- cutaneous melanoma
- cutaneous melanoma cancer
- skin squamous cell carcinoma
- squamous cell skin cancer
- glioblastoma
- glioblastoma cancer
- neoplastic cell transformation
- skin basal cell carcinoma
- basal cell skin cancer
role in cell
- expression in
- proliferation
- activation in
- apoptosis
- growth
- quantity
- S phase
- DNA damage response
- G1/S phase transition
- cell focus formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- cell division
- G0 to G1 transition
- signal transduction
- G1/S transition of mitotic cell cycle
- regulation of gene expression
- negative regulation of Notch signaling pathway
- protein phosphorylation
- response to DNA damage stimulus
- regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cyclin-dependent protein kinase holoenzyme complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- cyclin binding
- cyclin-dependent protein kinase activity