RECQL5 Gene Summary [Human]
The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Details
| Type | Retained Intron |
| Official Symbol | RECQL5 |
| Official Name | RecQ like helicase 5 [Source:HGNC Symbol;Acc:HGNC:9950] |
| Ensembl ID | ENSG00000108469 |
| Bio databases IDs | |
| Aliases | RecQ like helicase 5, RecQ protein 5 |
| Synonyms | DKFZP434J0450, RECQ5, Recq5b, Recql5b, RecQ like helicase 5, RecQ protein-like 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RECQL5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP-dependent DNA helicase, RecQ family
- helicase
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- enzyme binding
- enzyme
- protein binding
- identical protein binding
- Helicase conserved C-terminal domain
- DNA helicase
- helicase domain
- RecQ zinc-binding
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- RecQ helicase protein-like 5 (RecQ5)
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
role in cell
- expression in
- accumulation in
- transcription in
- formation
- stalling
- response by
- stalling in
- formation in
- damage in
- cohesion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RECQL5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- DNA repair
- negative regulation of transcription elongation from RNA polymerase II promoter
- negative regulation of double-strand break repair via homologous recombination
- DNA replication
- double-strand break repair via homologous recombination
- cellular response to xenobiotic stimulus
- DNA metabolic process
- mitotic cell cycle
- DNA unwinding involved in replication
- chromosome separation
Cellular Component
Where in the cell the gene product is active
- replication fork
- nucleus
- cytoplasm
- cytosol
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- ATP binding
- DNA helicase activity
- metal ion binding
- helicase activity
- four-way junction helicase activity
- 3'-5' DNA helicase activity
- RNA polymerase II core binding
- isomerase activity