RNASE4 Gene Summary [Human]
The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | RNASE4 |
| Official Name | ribonuclease A family member 4 [Source:HGNC Symbol;Acc:HGNC:10047] |
| Ensembl ID | ENSG00000258818 |
| Bio databases IDs | |
| Aliases | ribonuclease A family member 4 |
| Synonyms | C730049F20RIK, RAB1, RIBONUCLEASE 4, ribonuclease A family member 4, ribonuclease, RNase A family 4, RNS4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNASE4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Non-5' phosphomonoester producing endoribonuclease
- ribonuclease
- enzyme
- RNase_A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- ER-to-Golgi intermediate compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNASE4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- antibacterial humoral response
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- ribonuclease activity
- pancreatic ribonuclease activity