CD109 Gene Summary [Human]
This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | CD109 |
| Official Name | CD109 molecule [Source:HGNC Symbol;Acc:HGNC:21685] |
| Ensembl ID | ENSG00000156535 |
| Bio databases IDs | |
| Aliases | CD109 molecule |
| Synonyms | 9930012E15Rik, CD109 antigen, CD109 molecule, CPAMD7, GARP, p180, r150 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD109 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha-2-macroglobulin bait region domain
- ISOPREN_C2_like
- A-macroglobulin TED domain
- A-macroglobulin receptor binding domain
- TGFbeta binding
- Alpha-2-macroglobulin family
- MG2 domain
- Macroglobulin domain MG3
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- myocardial infarction
- multiple sclerosis
- epithelial thyroid cancer
- uterine leiomyoma
- leiomyomatosis
- epithelial basal cell carcinoma
role in cell
- phosphorylation in
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cytosol
- alpha granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD109 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of wound healing
- negative regulation of keratinocyte proliferation
- regulation of keratinocyte differentiation
- keratinocyte proliferation
- hair follicle development
- osteoclast fusion
- negative regulation of stem cell proliferation
- negative regulation of protein phosphorylation
- stem cell proliferation
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- platelet alpha granule membrane
- cytosol
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- transforming growth factor beta binding
- serine-type endopeptidase inhibitor activity