Rnase4 Gene Summary [Mouse]

This gene encodes a member of the pancreatic ribonuclease A superfamily. The encoded enzyme is sereted and has unique uridine specificity. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the angiogenin, ribonuclease, RNase A family, 5 gene. Each gene splices to a unique downstream exon that contains its complete coding region. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. [provided by RefSeq, Jun 2009]

Details

Type
Protein Coding
Official Symbol
Rnase4
Official Name
ribonuclease, RNase A family 4 [Source:MGI Symbol;Acc:MGI:1926217]
Ensembl ID
ENSMUSG00000021876
Bio databases IDs NCBI: 58809 Ensembl: ENSMUSG00000021876
Aliases ribonuclease, RNase A family 4
Synonyms C730049F20RIK, RAB1, RIBONUCLEASE 4, ribonuclease A family member 4, ribonuclease, RNase A family 4, RNS4
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnase4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Non-5' phosphomonoester producing endoribonuclease
  • ribonuclease
  • enzyme
  • RNase_A

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • psychosis
  • uterine serous papillary cancer
regulated by
role in cell
  • inhibition in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • ER-to-Golgi intermediate compartment

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnase4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • antibacterial humoral response
  • defense response to Gram-positive bacterium

Cellular Component

Where in the cell the gene product is active
  • extracellular space
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • nucleic acid binding
  • ribonuclease activity
  • pancreatic ribonuclease activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.