RAB7B Gene Summary [Human]
Predicted to enable GTP binding activity and GTPase activity. Involved in late endosome to Golgi transport; positive regulation of megakaryocyte differentiation; and regulation of gene expression. Located in cytoplasmic vesicle; lysosome; and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RAB7B |
| Official Name | RAB7B, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:30513] |
| Ensembl ID | ENSG00000276600 |
| Bio databases IDs | |
| Aliases | RAB7B, member RAS oncogene family |
| Synonyms | 5430435G22Rik, RAB7, RAB7B, member RAS oncogene family, RGD1562617 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB7B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- peptidase
- protein binding
- Ras subfamily of RAS small GTPases
- ADP-ribosylation factor family
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Elongation factor Tu GTP binding domain
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- Rho (Ras homology) subfamily of Ras-like small GTPases
- Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the RAB7B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by murine hepatitis virus
- infection by feline infectious peritonitis virus
role in cell
- phosphorylation in
- degradation in
- activation in
- expression in
- differentiation
- response by
- fusion
- trafficking in
- maturation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- vesicles
- lysosome
- Golgi Apparatus
- trans Golgi network
- endosomal membrane
- late endosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB7B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of toll-like receptor 4 signaling pathway
- protein transport
- negative regulation of toll-like receptor 9 signaling pathway
- positive regulation of megakaryocyte differentiation
- phagosome-lysosome fusion
- endosome to lysosome transport
- late endosome to Golgi transport
- cellular response to interferon-gamma
- positive regulation of interleukin-6 production
- positive regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- trans-Golgi network
- late endosome
- phagocytic vesicle
- phagocytic vesicle membrane
- Golgi apparatus
- lysosome
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity