CHI3L1 Gene Summary [Human]
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]
Details
| Type | Retained Intron |
| Official Symbol | CHI3L1 |
| Official Name | chitinase 3 like 1 [Source:HGNC Symbol;Acc:HGNC:1932] |
| Ensembl ID | ENSG00000133048 |
| Bio databases IDs | |
| Aliases | chitinase 3 like 1, cartilage glycoprotein-39 |
| Synonyms | ASRT7, Brp39, cartilage glycoprotein-39, CGP-39, Chil1, Chitinase 3 like 1, GP-39, hCGP-39, HCGP-3P, YK-40, YKL-40, YYL-40 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHI3L1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl hydrolases family 18
- GH18_chitinase-like
- enzyme
- protein binding
- chitin binding
- Glyco_18 domain
Pathways
Biological processes and signaling networks where the CHI3L1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- insulin resistance
- COVID-19
- Huntington disease
- Alzheimer disease
- schizophrenia
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- cutaneous sarcoidosis
role in cell
- proliferation
- activation in
- apoptosis
- number
- formation
- formation in
- recruitment
- phosphorylation in
- expression in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- Cytoplasm
- Plasma Membrane
- Endoplasmic Reticulum
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHI3L1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chitin catabolic process
- activation of NF-kappaB-inducing kinase activity
- positive regulation of angiogenesis
- response to mechanical stimulus
- carbohydrate metabolic process
- positive regulation of interleukin-8 production
- inflammatory response
- positive regulation of ERK1 and ERK2 cascade
- apoptotic process
- response to interleukin-1
- positive regulation of peptidyl-threonine phosphorylation
- cellular response to tumor necrosis factor
- response to interleukin-6
- positive regulation of protein kinase B signaling cascade
- cartilage development
- response to tumor necrosis factor
- lung development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- specific granule lumen
- endoplasmic reticulum
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- chitinase activity
- chitin binding
- protein binding
- carbohydrate binding
- extracellular matrix structural constituent