MIR34A Gene Summary [Human]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. [provided by RefSeq, Sep 2015]
Details
| Type | Micro RNA |
| Official Symbol | MIR34A |
| Official Name | microRNA 34a [Source:HGNC Symbol;Acc:HGNC:31635] |
| Ensembl ID | ENSG00000284357 |
| Bio databases IDs | |
| Aliases | microRNA 34a |
| Synonyms | hsa-mir-172, HSA-MIR-34A, HSA-MIR-34AN, hsa-miR-34b, hsa-miR-34b-opposite, hsa-miR-34c, microRNA 34, MicroRNA 34a, microRNA 34ab, microRNA 34b, microRNA 34B/C, microRNA 34c, microRNA 34 group, MIR-034, MIR34A, MIR34ab, MIR34B, MIR34B/C, MIR34C, miR-34 family, MIRN34A, MIRN34B, MIRN34C, miRNA34A, miRNA34B, miRNA34C, mmu-miR-34a, mmu-miR-34b, mmu-miR-34c, pre-miR-34a, rno-miR-34a, rno-miR-34b, rno-miR-34c |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MIR34A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- translation repressor
- mRNA binding
- microRNA
Pathways
Biological processes and signaling networks where the MIR34A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- head and neck squamous cell cancer
- non-small cell lung carcinoma
- non-small cell lung cancer
- gastric cancer
- cervical squamous cell carcinoma
- large cell lung carcinoma
- epithelial cancer
- small cell lung cancer
role in cell
- expression in
- number
- accumulation in
- activation in
- quantity
- apoptosis
- response by
- production in
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MIR34A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- response to axon injury
- cholesterol homeostasis
- negative regulation of smooth muscle cell chemotaxis
- positive regulation of cellular senescence
- negative regulation of B cell receptor signaling pathway
- negative regulation of transmembrane transport
- regulation of cell cycle
- cellular response to hypoxia
- negative regulation of IP-10 production
- triglyceride homeostasis
- negative regulation of peroxisome proliferator activated receptor signaling pathway
- gene silencing by miRNA
- negative regulation of chemokine production
- negative regulation of vascular wound healing
- negative regulation of beta-amyloid clearance
- response to DNA damage stimulus
- negative regulation of calcium ion import
- negative regulation of gene expression
- tumor necrosis factor-mediated signaling pathway
- positive regulation of leukocyte apoptotic process
- positive regulation of gene expression
- positive regulation of smooth muscle cell differentiation
- positive regulation of cardiac muscle cell apoptotic process
- negative regulation of protein serine/threonine kinase activity
- positive regulation of lipid storage
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- mRNA 3'-UTR binding