Kl Gene Summary [Mouse]
Enables fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Acts upstream of or within several processes, including determination of adult lifespan; energy reserve metabolic process; and positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway. Predicted to be located in extracellular region and membrane. Is expressed in brain; cerebral cortex; femur; hippocampus; and metanephros. Used to study hyperphosphatemic familial tumoral calcinosis and pulmonary emphysema. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kl |
| Official Name | klotho [Source:MGI Symbol;Acc:MGI:1101771] |
| Ensembl ID | ENSMUSG00000058488 |
| Bio databases IDs | |
| Aliases | klotho |
| Synonyms | alpha-kl, alpha KLOTHO, HFTC3, KLA, KLOTHO, α-kl, α KLOTHO |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- fibroblast growth factor binding
- kinase-like domain
- KL1 domain
- enzyme
- protein binding
- fibroblast growth factor receptor binding
- Glycosyl hydrolase family 1
- beta-galactosidase
- beta-glucosidase
- Glycosyl hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- fibrosis
- colorectal cancer
- metastasis
- hyperphosphatemia
- atherosclerosis
- osteoporosis
- cardiac fibrosis
- pulmonary emphysema
phenotypes
- Purkinje cell degeneration
- abnormal adenohypophysis morphology
- abnormal aorta wall morphology
- abnormal autopod morphology
- abnormal blood circulation
- abnormal blood vessel physiology
- abnormal bone mineral density
- abnormal bone ossification
- abnormal bone structure
- abnormal cardiovascular system physiology
- abnormal circulating mineral level
- abnormal circulating protein level
- abnormal contextual conditioning behavior
- abnormal cued conditioning behavior
- abnormal definitive hematopoiesis
- abnormal duodenum morphology
- abnormal femur morphology
- abnormal gametogenesis
- abnormal glucose homeostasis
- abnormal gonadotroph morphology
- abnormal heart morphology
- abnormal heart valve morphology
- abnormal incus morphology
- abnormal kidney collecting duct morphology
- abnormal kidney cortex morphology
- abnormal kidney medulla morphology
- abnormal kidney morphology
- abnormal leukocyte cell number
- abnormal liver physiology
- abnormal long bone epiphyseal plate proliferative zone
- abnormal long bone epiphysis morphology
- abnormal long term object recognition memory
- abnormal lung morphology
- abnormal malleus manubrium morphology
- abnormal malleus morphology
- abnormal middle ear ossicle morphology
- abnormal nervous system physiology
- abnormal osteoblast morphology
- abnormal osteoblast physiology
- abnormal osteoclast morphology
- abnormal pancreatic beta cell morphology
- abnormal pulmonary alveolus morphology
- abnormal pulmonary interalveolar septum morphology
- abnormal respiratory mechanics
- abnormal retina morphology
- abnormal rib morphology
- abnormal seminiferous tubule morphology
- abnormal sinoatrial node conduction
- abnormal skin condition
- abnormal smooth muscle morphology
- abnormal spleen morphology
- abnormal stomach morphology
- abnormal trabecular bone morphology
- abnormal tracheal cartilage morphology
- abnormal vertebrae morphology
- abnormal vitamin D level
- absent bone trabeculae
- absent mature ovarian follicles
- absent pinna reflex
- alopecia
- arrest of male meiosis
- arteriosclerosis
- azoospermia
- calcified aorta
- calcified aortic valve
- calcified artery
- calcified mitral valve
- calcified muscle
- calcified pulmonary alveolus
- calcified skin
- calcinosis
- decreased B cell number
- decreased Purkinje cell number
- decreased a wave amplitude
- decreased b wave amplitude
- decreased body length
- decreased body size
- decreased body temperature
- decreased body weight
- decreased bone mineral content
- decreased bone mineral density
- decreased brown fat cell lipid droplet size
- decreased circulating glucose level
- decreased circulating insulin level
- decreased circulating serum albumin level
- decreased compact bone thickness
- decreased femur compact bone thickness
- decreased hair follicle number
- decreased heart rate
- decreased insulin secretion
- decreased liver weight
- decreased long bone epiphyseal plate size
- decreased osteoblast cell number
- decreased osteoclast cell number
- decreased somatotroph cell size
- decreased somatotroph secretory granule number
- decreased subcutaneous adipose tissue amount
- decreased tidal volume
- decreased white adipose tissue amount
- decreased width of hypertrophic chondrocyte zone
- dehydration
- diaphragmatic hernia
- dilated gastric glands
- dilated pulmonary alveolar ducts
- emphysema
- external male genitalia atrophy
- hemorrhage
- hunched posture
- hypoactivity
- hypoglycemia
- impaired hearing
- improved glucose tolerance
- increased a wave latency
- increased alkaline phosphatase activity
- increased b wave latency
- increased brown adipose tissue amount
- increased circulating calcium level
- increased circulating noradrenaline level
- increased circulating phosphate level
- increased insulin sensitivity
- increased lung compliance
- increased sensitivity to induced morbidity/mortality
- increased vitamin D level
- infertility
- kidney cortex hypoplasia
- kyphoscoliosis
- kyphosis
- lung inflammation
- nephrocalcinosis
- osteopetrosis
- osteoporosis
- ovary atrophy
- oxidative stress
- postnatal growth retardation
- premature aging
- premature death
- prolonged RR interval
- renal fibrosis
- renal necrosis
- respiratory distress
- short femur
- short malleus
- short malleus manubrium
- short stride length
- skin atrophy
- small kidney
- small pancreatic islets
- small spleen
- small stapes obturator foramen
- sparse hair
- testicular atrophy
- thick zygomatic arch
- thin epidermis
- thymus atrophy
- uterus atrophy
- vulva atrophy
- wide ribs
role in cell
- cell viability
- expression in
- activation in
- phosphorylation in
- proliferation
- binding in
- accumulation in
- growth
- production in
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cellular membrane
- Plasma Membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
- carbohydrate metabolic process
- calcium ion homeostasis
- response to vitamin D
- determination of adult lifespan
- negative regulation of systemic arterial blood pressure
- energy reserve metabolic process
- fibroblast growth factor receptor signaling pathway
- response to activity
- norepinephrine biosynthetic process
- positive regulation of bone mineralization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular region
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- beta-glucosidase activity
- fibroblast growth factor binding
- vitamin D binding
- hormone activity
- beta-glucuronidase activity
- fibroblast growth factor receptor binding