Mnt Gene Summary [Mouse]
Enables DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Acts upstream of or within several processes, including cellular senescence; negative regulation of apoptotic signaling pathway; and regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; future brain; genitourinary system; and retina nuclear layer. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human MNT (MAX network transcriptional repressor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mnt |
| Official Name | max binding protein [Source:MGI Symbol;Acc:MGI:109150] |
| Ensembl ID | ENSMUSG00000000282 |
| Bio databases IDs | |
| Aliases | max binding protein |
| Synonyms | bHLHd3, lncRNA-HAL, MAD6, max binding protein, MAX network transcriptional repressor, MXD6, ROX |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mnt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- proline/glutamine rich region
- transcription regulator
- nucleic acid binding
- Sin3 binding domain
- basic Helix Loop Helix (bHLH) domain superfamily
- chromatin binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- basic helix-loop-helix-leucine zipper domain
- double-stranded DNA binding
- helix loop helix domain
- Helix-loop-helix DNA-binding domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- epithelial neoplasia
- Sézary syndrome
- atopic dermatitis
- cleft palate
- lymphatic neoplasia
- lymphomagenesis
role in cell
- expression in
- migration
- proliferation
- necrosis
- survival
- cell cycle progression
- apoptosis
- epithelial-mesenchymal transition
- transformation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mnt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cellular senescence
- transcription from RNA polymerase II promoter
- regulation of cell cycle
- negative regulation of apoptotic signaling pathway
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity