Mlx Gene Summary [Mouse]
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of glycolytic process; positive regulation of lipid biosynthetic process; and positive regulation of transcription from RNA polymerase II promoter by glucose. Acts upstream of or within nucleocytoplasmic transport. Located in cytoplasm. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Used to study oligoasthenoteratozoospermia. Human ortholog(s) of this gene implicated in Takayasu's arteritis. Orthologous to human MLX (MAX dimerization protein MLX). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mlx |
| Official Name | MAX-like protein X [Source:MGI Symbol;Acc:MGI:108398] |
| Ensembl ID | ENSMUSG00000017801 |
| Bio databases IDs | |
| Aliases | MAX-like protein X |
| Synonyms | bHLHd13, BigMax, MAD7, MAX dimerization protein MLX, MAX-like protein X, Mlx beta, Mlx β, MXD7, TCFL4, TF4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mlx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- transcription factor binding
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- helix loop helix domain
- protein homodimerization
- Helix-loop-helix DNA-binding domain
- basic domain
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- coronary artery disease
- periodontitis
- teratozoospermia
- liver cancer
- Parkinson disease
- hepatocellular carcinoma
- leiomyoma
role in cell
- growth
- expression in
- activation in
- number
- molecular cleavage in
- survival
- myogenesis
- colony formation by
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
- nuclear envelope
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mlx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity