Zfp385a Gene Summary [Mouse]
Enables mRNA 3'-UTR binding activity. Involved in DNA damage response and apoptotic process. Acts upstream of or within several processes, including myeloid cell differentiation; platelet alpha granule organization; and post-transcriptional regulation of gene expression. Located in dendrite and neuronal cell body. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human ZNF385A (zinc finger protein 385A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp385a |
| Official Name | zinc finger protein 385A [Source:MGI Symbol;Acc:MGI:1352495] |
| Ensembl ID | ENSMUSG00000000552 |
| Bio databases IDs | |
| Aliases | zinc finger protein 385A |
| Synonyms | HZF, LOC683930, RZF, ZFP385, Zfp385a, zinc finger protein 385A, ZNF385 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp385a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA 3' UTR binding
- Zinc-finger double-stranded RNA-binding
- U1 zinc finger
- p53 binding
- Zinc-finger of C2H2 type
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding disorder
- bleeding
regulates
- NFkB (complex)
role in cell
- apoptosis
- formation
- quantity
- replication in
- activation in
- differentiation
- abnormal morphology
- localization in
- production
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- chromatin
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp385a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- posttranscriptional regulation of gene expression by mRNA localization
- locomotory behavior
- apoptotic process
- platelet formation
- megakaryocyte development
- positive regulation of fat cell differentiation
- regulation of cytoplasmic translation
- platelet alpha granule organization
- response to DNA damage stimulus
- hemostasis
- learning or memory
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- cytosol
- neuronal cell body
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- p53 binding
- zinc ion binding
- RNA binding
- mRNA 3'-UTR binding