Cep57 Gene Summary [Mouse]
Enables microtubule binding activity. Involved in protein homooligomerization and spermatid development. Located in centrosome; cytoplasm; and nucleus. Is expressed in midbrain ventricular layer and telencephalon ventricular layer. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome 2. Orthologous to human CEP57 (centrosomal protein 57). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cep57 |
| Official Name | centrosomal protein 57 [Source:MGI Symbol;Acc:MGI:1915551] |
| Ensembl ID | ENSMUSG00000031922 |
| Bio databases IDs | |
| Aliases | centrosomal protein 57 |
| Synonyms | 3110002L15Rik, 4921510P06Rik, 4931428M20Rik, centrosomal protein 57, KIAA0092, mKIAA0092, MVA2, PIG8, RGD1309884, TSP57 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cep57 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Centrosome microtubule-binding domain of Cep57
- microtubule binding
- fibroblast growth factor binding
- protein homodimerization
- protein binding
- Centrosome localization domain of Cep57
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- prostate cancer
- mosaic variegated aneuploidy syndrome type 1
- mosaic variegated aneuploidy syndrome type 2
- mosaic variegated aneuploidy
regulates
- alpha tubulin
role in cell
- development
- overduplication
- acetylation in
- overduplication in
- stability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- Golgi Apparatus
- microtubules
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cep57 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid development
- protein homooligomerization
- fibroblast growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- centriolar satellite
- cytosol
- Golgi apparatus
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- gamma-tubulin binding
- fibroblast growth factor binding
- microtubule binding