Rag2 Gene Summary [Mouse]
Enables several functions, including methylated histone binding activity; phosphatidylinositol phosphate binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in T cell differentiation in thymus; V(D)J recombination; and pre-B cell allelic exclusion. Acts upstream of or within several processes, including B cell homeostatic proliferation; lymphocyte differentiation; and positive regulation of organ growth. Predicted to be located in nucleoplasm. Predicted to be part of DNA recombinase complex. Is expressed in gut; hemolymphoid system; and liver. Used to study Omenn syndrome and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Human ortholog(s) of this gene implicated in Omenn syndrome; combined cellular and humoral immune defects with granulomas; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Orthologous to human RAG2 (recombination activating 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rag2 |
| Official Name | recombination activating gene 2 [Source:MGI Symbol;Acc:MGI:97849] |
| Ensembl ID | ENSMUSG00000032864 |
| Bio databases IDs | |
| Aliases | recombination activating gene 2 |
| Synonyms | recombination activating 2, recombination activating gene 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rag2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- Recombination activating protein 2
- protein binding activity, bridging
- chromatin binding
- enzyme
- protein binding
- core domain, functional
- phosphatidylinositol binding
- binding protein
- zinc ion binding
- phosphatidylinositol-3,4,5-triphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- PHD finger superfamily
Pathways
Biological processes and signaling networks where the Rag2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial cancer
- diarrhea
- infection
- colitis
- breast cancer
- bleeding
- bacteremia
- dextran sodium sulfate-induced colitis
role in cell
- cell death
- differentiation
- expression in
- proliferation
- apoptosis
- number
- binding in
- production in
- quantity
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rag2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- V(D)J recombination
- negative regulation of T cell differentiation in thymus
- organ growth
- B cell differentiation
- T cell differentiation in thymus
- positive regulation of organ growth
- T cell lineage commitment
- chromatin organization
- defense response to bacterium
- pre-B cell allelic exclusion
- mature B cell differentiation involved in immune response
- B cell homeostatic proliferation
- B cell lineage commitment
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- zinc ion binding
- methylated histone residue binding
- phosphatidylinositol binding
- phosphatidylinositol-3,5-bisphosphate binding
- sequence-specific DNA binding
- chromatin binding
- phosphatidylinositol-3,4-bisphosphate binding