Klf1

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in erythrocyte differentiation; positive regulation of gene expression; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; in utero embryonic development; and liver development. Predicted to be located in chromatin and nucleoplasm. Is expressed in several structures, including extraembryonic component; hemolymphoid system; olfactory placode; testis; and urethra. Used to study beta thalassemia and hereditary spherocytosis. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IVa and congenital dyserythropoietic anemia type IVb. Orthologous to human KLF1 (KLF transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Klf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Klf1 gene, providing context for its role in the cell.