Gse1 Gene Summary [Mouse]
Acts upstream of or within gene expression; in utero embryonic development; and placenta development. Is expressed in cerebral cortex subventricular zone and cortical plate. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human GSE1 (Gse1 coiled-coil protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gse1 |
| Official Name | genetic suppressor element 1, coiled-coil protein [Source:MGI Symbol;Acc:MGI:1098275] |
| Ensembl ID | ENSMUSG00000031822 |
| Bio databases IDs | |
| Aliases | genetic suppressor element 1, coiled-coil protein |
| Synonyms | 2210013I18Rik, CRHSP24, genetic suppressor element 1, coiled-coil protein, Gse1 coiled-coil protein, KIAA0182, LOC105371387, mKIAA0182, RGD1562686 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gse1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF3736)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- hypertension
- male pattern hair loss
- alopecia areata
- COVID-19
- metastasis
- metabolic syndrome X
- schizophrenia
- gastric cancer
regulated by
- MC2580
- TGFB1
- DDP-38003
- lipopolysaccharide
- camptothecin
- mir-8 (includes others)
- OG86
- topotecan
- GNE-987
role in cell
- proliferation
- expression in
- migration
- cell viability
- binding in
- colony formation
- differentiation
- invasion by
- deubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gse1 gene, providing context for its role in the cell.
Molecular Function
What the gene product does at the molecular level
- protein binding