Piwil4 Gene Summary [Mouse]
Enables molecular adaptor activity and piRNA binding activity. Involved in negative regulation of gene expression and spermatogenesis. Acts upstream of with a positive effect on transposable element silencing by heterochromatin formation. Located in nucleus and piP-body. Is expressed in embryo; germ cell of testis; testis; and trunk unsegmented mesenchyme. Orthologous to human PIWIL4 (piwi like RNA-mediated gene silencing 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Piwil4 |
| Official Name | piwi-like RNA-mediated gene silencing 4 [Source:MGI Symbol;Acc:MGI:3041167] |
| Ensembl ID | ENSMUSG00000036912 |
| Bio databases IDs | |
| Aliases | piwi-like RNA-mediated gene silencing 4 |
| Synonyms | 9230101H05, 9230101H05Rik, HIWI2, mAgo5, MIWI2, PIWI4, piwi-like RNA-mediated gene silencing 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Piwil4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Piwi-like
- PAZ domain
- protein binding
- PAZ
- Piwi domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- colorectal cancer
- acute myeloid leukemia
- small cell lung cancer
- small cell lung carcinoma
- leukemia
role in cell
- phosphorylation in
- expression in
- apoptosis
- proliferation
- number
- AZ20 sensitivity
- migration
- colony formation
- damage in
- engraftment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Piwil4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- meiotic cell cycle
- epithelial structure maintenance
- spermatogenesis
- cell differentiation
- gene silencing by RNA
- piRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- P granule
- mitochondrion
- piP-body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- piRNA binding
- endoribonuclease activity