Icam2 Gene Summary [Mouse]
Predicted to enable integrin binding activity. Predicted to be involved in cell adhesion. Located in microvillus; plasma membrane; and uropod. Is expressed in cardiovascular system; central nervous system; extraembryonic component; female reproductive system; and retina. Orthologous to human ICAM2 (intercellular adhesion molecule 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Icam2 |
| Official Name | intercellular adhesion molecule 2 [Source:MGI Symbol;Acc:MGI:96394] |
| Ensembl ID | ENSMUSG00000001029 |
| Bio databases IDs | |
| Aliases | intercellular adhesion molecule 2 |
| Synonyms | CD102, intercellular adhesion molecule 2, Ly-60 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Icam2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Intercellular adhesion molecule (ICAM), N-terminal domain
- cytoplasmic domain
- immunoglobulin domain
- integrin binding
- transmembrane domain
- protein binding
Pathways
Biological processes and signaling networks where the Icam2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- lung cancer
- gastric cancer
- chronic obstructive pulmonary disease
- metastasis
- organismal death
- preeclampsia
- androgenic alopecia
- limited systemic sclerosis
role in cell
- proliferation
- expression in
- apoptosis
- differentiation
- aggregation
- tethering
- adhesion
- organization
- elongation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cell periphery
- cellular membrane
- intercellular junctions
- apical cell surfaces
- uropod
- cleavage furrow
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Icam2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- uropod
- cleavage furrow
- microvillus
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- integrin binding