Agpat3 Gene Summary [Mouse]
Enables lysophosphatidic acid acyltransferase activity. Predicted to be involved in CDP-diacylglycerol biosynthetic process. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Agpat3 |
| Official Name | 1-acylglycerol-3-phosphate O-acyltransferase 3 [Source:MGI Symbol;Acc:MGI:1336186] |
| Ensembl ID | ENSMUSG00000001211 |
| Bio databases IDs | |
| Aliases | 1-acylglycerol-3-phosphate O-acyltransferase 3 |
| Synonyms | 1-acylglycerol-3-phosphate O-acyltransferase 3, 1-AGPAT 3, D10Jhu12e, LPAAT3, LPAAT-GAMMA1, LPLAT3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Agpat3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- lysophosphatidic acid acyltransferase
- 1-acylglycerol-3-phosphate O-acyltransferase
- enzyme
- protein binding
- Acyltransferase
- Acyltransferase C-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Down syndrome
- rheumatoid arthritis
- herpes zoster
- mental retardation
- endometrioma
- side effect
role in cell
- expression in
- elongation
- abnormal morphology
- disappearance in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- Golgi membrane
- nuclear envelope
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Agpat3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid biosynthetic process
- CDP-diacylglycerol biosynthetic process
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- membrane
- endomembrane system
- Golgi membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- protein binding