Axl Gene Summary [Mouse]
Predicted to enable several functions, including phosphatidylinositol 3-kinase binding activity; phosphatidylserine binding activity; and virus receptor activity. Involved in negative regulation of apoptotic process and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within several processes, including negative regulation of cytokine production; nervous system development; and neutrophil clearance. Predicted to be located in several cellular components, including actin cytoskeleton; cell surface; and extracellular space. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Used to study autoimmune disease. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AXL (AXL receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Axl |
| Official Name | AXL receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:1347244] |
| Ensembl ID | ENSMUSG00000002602 |
| Bio databases IDs | |
| Aliases | AXL receptor tyrosine kinase |
| Synonyms | ARK, AXL3, AXL receptor tyrosine kinase, JTK11, LOC687188, Tyro7, UFO |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Axl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- JMTM_Notch_APP
- viral receptor
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- myosin binding
- cytoplasmic domain
- Immunoglobulin like
- intracellular domain
- immunoglobulin-like protein domain
- Tyrosine kinase, catalytic domain
- Immunoglobulin V-set domain
- growth factor binding
- phospholipid binding
- extracellular domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- ectodomain
- Immunoglobulin I-set domain
- protein binding
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- phosphoinositide 3-kinase binding
- binding protein
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- FN3
- transmembrane domain
- tyrosine kinase domain
Pathways
Biological processes and signaling networks where the Axl gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thrombosis
- neoplasia
- colorectal cancer
- infection
- hepatocellular carcinoma
- metastasis
- diabetes mellitus
- multiple sclerosis
- experimental autoimmune encephalomyelitis
- autoimmune disease
role in cell
- number
- binding
- activity
- expression in
- apoptosis
- cell viability
- production in
- growth
- phosphorylation in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cell surface
- Extracellular Space
- cellular membrane
- actin cytoskeleton
- Nucleus
- membrane processes
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Axl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- vagina development
- multicellular organismal development
- nervous system development
- negative regulation of lymphocyte activation
- response to axon injury
- ovulation cycle
- negative regulation of neuron apoptotic process
- positive regulation of natural killer cell differentiation
- positive regulation of cytokine-mediated signaling pathway
- neuron migration
- inflammatory response
- negative regulation of macrophage cytokine production
- dendritic cell differentiation
- substrate adhesion-dependent cell spreading
- positive regulation of kinase activity
- establishment of localization in cell
- cellular response to hydrogen peroxide
- negative regulation of interferon-gamma production
- platelet activation
- cell migration
- cellular response to interferon-alpha
- secretion by cell
- neuron apoptotic process
- negative regulation of tumor necrosis factor production
- erythrocyte homeostasis
- signal transduction
- spermatogenesis
- forebrain cell migration
- transmembrane receptor protein tyrosine kinase signaling pathway
- cell maturation
- positive regulation of pinocytosis
- vascular endothelial growth factor receptor signaling pathway
- blood vessel remodeling
- cellular response to lipopolysaccharide
- negative regulation of dendritic cell apoptotic process
- negative regulation of apoptotic process
- innate immune response
- natural killer cell differentiation
- phagocytosis
- organ regeneration
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- actin cytoskeleton
- receptor complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol 3-kinase binding
- ATP binding
- protein tyrosine kinase activity
- phosphatidylserine binding
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- myosin heavy chain binding
- viral receptor activity