Tspan5 Gene Summary [Mouse]
Enables enzyme binding activity. Involved in protein maturation. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; heart; inner ear; limb; and physiological umbilical hernia. Orthologous to human TSPAN5 (tetraspanin 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tspan5 |
| Official Name | tetraspanin 5 [Source:MGI Symbol;Acc:MGI:1928096] |
| Ensembl ID | ENSMUSG00000028152 |
| Bio databases IDs | |
| Aliases | tetraspanin 5 |
| Synonyms | 2810455A09Rik, 4930505M03Rik, NET-4, Tetraspanin 5, TM4SF9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tspan5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- enzyme binding
- protein binding
- Tetraspanin family
Pathways
Biological processes and signaling networks where the Tspan5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic scoliosis
- organismal death
- ischemic stroke
- insomnia
- renal cell carcinoma
- renal cell cancer
- stroke
- dementia
- ototoxicity
regulates
- MHC I (family)
- HLA-A
- CDH5
role in cell
- proliferation
- migration
- expression in
- invasion by
- colony formation by
- clustering in
- adhesion
- transmigration
- osteoclastogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- actin cytoskeleton
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tspan5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of membrane protein ectodomain proteolysis
- protein maturation
- positive regulation of Notch signaling pathway
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- actin cytoskeleton
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme binding