AGPAT3 Gene Summary [Human]
The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | AGPAT3 |
| Official Name | 1-acylglycerol-3-phosphate O-acyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:326] |
| Ensembl ID | ENSG00000160216 |
| Bio databases IDs | |
| Aliases | 1-acylglycerol-3-phosphate O-acyltransferase 3 |
| Synonyms | 1-acylglycerol-3-phosphate O-acyltransferase 3, 1-AGPAT 3, D10Jhu12e, LPAAT3, LPAAT-GAMMA1, LPLAT3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AGPAT3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- lysophosphatidic acid acyltransferase
- 1-acylglycerol-3-phosphate O-acyltransferase
- enzyme
- protein binding
- Acyltransferase
- Acyltransferase C-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Down syndrome
- rheumatoid arthritis
- herpes zoster
- mental retardation
- endometrioma
- side effect
role in cell
- expression in
- elongation
- abnormal morphology
- disappearance in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- Golgi membrane
- nuclear envelope
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AGPAT3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid biosynthetic process
- CDP-diacylglycerol biosynthetic process
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- membrane
- endomembrane system
- Golgi membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- protein binding