Atp2a1 Gene Summary [Mouse]
Enables calcium ion binding activity. Predicted to be involved in several processes, including calcium ion transport; intracellular calcium ion homeostasis; and regulation of striated muscle contraction. Predicted to act upstream of or within regulation of muscle contraction. Located in sarcoplasmic reticulum membrane. Is expressed in several structures, including diaphragm; heart; limb mesenchyme; musculature; and sciatic nerve. Human ortholog(s) of this gene implicated in Brody myopathy. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp2a1 |
| Official Name | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [Source:MGI Symbol;Acc:MGI:105058] |
| Ensembl ID | ENSMUSG00000030730 |
| Bio databases IDs | |
| Aliases | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 |
| Synonyms | ATP2A, ATPase, Ca++ transporting, cardiac muscle, fast twitch 1, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, Calcium transporting ATPase, SERCA1, Serca1a |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp2a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- magnesium-translocating P-type ATPase
- Cation transporter/ATPase, N-terminus
- sarco/endoplasmic reticulum calcium-translocating P-type ATPase
- ATP binding
- heavy metal translocating P-type ATPase
- E1-E2 ATPase
- plasma-membrane proton-efflux P-type ATPase
- copper-(or silver)-translocating P-type ATPase
- plasma-membrane calcium-translocating P-type ATPase
- phospholipid-translocating P-type ATPase, flippase
- Na,H/K antiporter P-type ATPase alpha subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Cation transport ATPase (P-type)
- Cation transporting ATPase, C-terminus
- Ca2+-transporting ATPase
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- golgi membrane calcium-translocating P-type ATPase
- calcium ion binding
- protein binding
- P-type ATPase of unknown pump specificity (type V)
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- nucleotide-sugar transporter
- transmembrane domain
- protein homodimerization
- K+-transporting ATPase, B subunit
- Haloacid Dehalogenase-like Hydrolases
- transporter
Pathways
Biological processes and signaling networks where the Atp2a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Brody myopathy
- Huntington disease
- fatigue
- calcium overload
- allergy
- focal cortical dysplasia of Taylor
- squamous-cell carcinoma
- squamous cell cancer
- obesity
role in cell
- expression in
- apoptosis
- quantity
- cell death
- phosphorylation in
- morphology
- swelling
- depletion in
- molecular cleavage in
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- longitudinal sarcoplasmic reticulum fraction
- perinuclear region
- cellular membrane
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- Mitochondria
- sarcomere
- ER-to-Golgi intermediate compartment
- cytosol
- endoplasmic reticulum membrane
- mitochondria-associated membranes
- synaptic vesicles
- growth cone
- I band
- terminal cisternae
- sarcoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp2a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion import
- ion transmembrane transport
- elevation of endoplasmic reticulum calcium ion concentration
- reduction of endoplasmic reticulum calcium ion concentration
- relaxation of skeletal muscle
- cellular calcium ion homeostasis
- positive regulation of fast-twitch skeletal muscle fiber contraction
- apoptotic mitochondrial changes
- elevation of mitochondrial calcium ion concentration
- calcium ion transport
- calcium ion transmembrane transport
- maintenance of mitochondrion location
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- calcium channel complex
- sarcoplasmic reticulum
- platelet dense tubular network membrane
- mitochondrion
- membrane
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- calcium-dependent ATPase activity
- ATPase activity
- ATP binding
- protein binding
- protein homodimerization activity
- calcium ion binding
- calcium-transporting ATPase activity