Smg5 Gene Summary [Mouse]
Predicted to enable enzyme binding activity; telomerase RNA binding activity; and telomeric DNA binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; regulation of dephosphorylation; and regulation of telomere maintenance. Predicted to be located in cytoplasm and nucleus. Predicted to be part of telomerase holoenzyme complex. Orthologous to human SMG5 (SMG5 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smg5 |
| Official Name | Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) [Source:MGI Symbol;Acc:MGI:2447364] |
| Ensembl ID | ENSMUSG00000001415 |
| Bio databases IDs | |
| Aliases | Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) |
| Synonyms | EST1B, LOC686386, LPTS-RP1, mKIAA1089, SMG5 nonsense mediated mRNA decay factor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smg5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- conserved domain
- ubiquitin protein ligase binding
- Telomerase activating protein Est1
- protein phosphatase binding
- Large family of predicted nucleotide-binding domains
- histone deacetylase binding
- protein binding
- PIN (PilT N terminus) domain: Superfamily
- telomeric DNA binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smg5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- regulation of telomere maintenance via telomerase
- regulation of dephosphorylation
- regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- telomerase holoenzyme complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding
- telomeric RNA binding
- histone deacetylase binding
- telomeric DNA binding
- protein phosphatase 2A binding